Prescription enzymatic ointment that selectively digests necrotic tissue without damaging healthy tissue.
Healix360 supports access to advanced mobile wound care services for patients throughout our coverage area. Services are delivered by licensed physicians and nurse practitioners experienced in the evaluation and management of chronic and complex wounds. Care is coordinated and provided directly to patients in private residences, assisted living communities, and skilled nursing facilities. Santyl works by enzymatically cleaving the collagen strands that hold necrotic eschar and slough to the underlying viable tissue. Once those collagen anchors are dissolved, the dead tissue separates from the wound bed and can be gently removed at the next dressing change. Because the enzyme acts only on denatured collagen, healthy tissue is not affected.
A licensed clinician determines whether this treatment is appropriate after evaluating the wound and the patient's medical history.
Treatment decisions are individualized. Potential contraindications and precautions may include:
The clinician cleanses the wound with sterile saline (avoiding antiseptics that could inactivate the enzyme), applies a thin layer of Santyl ointment directly to the necrotic tissue, and covers with an appropriate moist dressing. Caregivers or facility staff then perform daily applications between clinical visits. Visible reduction in slough is typically seen within 7 to 14 days of consistent use.
Santyl (collagenase) is FDA-approved for the debridement of chronic dermal ulcers and severely burned areas. Published clinical studies have demonstrated effective and selective removal of devitalized tissue with a favorable safety profile, particularly in patients who are poor candidates for sharp debridement.
Yes. After the licensed clinician initiates therapy and provides written instructions, a trained caregiver or facility nurse can apply the prescribed daily dose between clinical visits.
Most patients see visible reduction in necrotic tissue within 7 to 14 days of consistent daily application. Some wounds require longer courses depending on the depth and adherence of the eschar.
Detergents, hexachlorophene, and antiseptics containing silver or heavy metals can inactivate the enzyme. The clinician will provide a list of compatible cleansers and dressings.
No. The enzyme works selectively on dead tissue and does not cause pain on application. Some patients notice mild warmth or transient stinging that quickly resolves.
Santyl is a prescription medication and is typically covered by Medicare Part D, Medicaid, and most commercial pharmacy benefits, often with a prior authorization. The coordination team helps secure coverage before the first prescription is filled.
Call 877-545-1300 or request a provider to begin care. Healix360 serves Southern California and Nevada and accepts Medicare Part B and most major insurance plans.